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A Polygenic Risk Score — a genetic assessment that doctors have hoped could predict coronary heart disease (CHD) in patients — has been found not to be a useful predictive biomarker for disease risk.

²¤ÂÜÊÓƵers at VUMC are reporting another advance in the understanding and treatment of triple-negative breast cancer, which is particularly aggressive and difficult to treat.

Katherine Gifford, PsyD, MS, assistant professor of Neurology, has been awarded a five-year, $4.3 million research grant from the National Institute on Aging to study what subjective cognitive decline can reveal about underlying pathology.

An investigational drug that binds bile acids in the stomach can reduce the severity of heartburn symptoms in patients with treatment-resistant gastroesophageal reflux disease (GERD) when combined with a proton pump inhibitor (PPI), a new study suggests.

The identification of novel protein interactions and sites of modification in proteins involved in mRNA translation adds to understanding of a process that is an important therapeutic target.

An opioid-restrictive prescribing protocol reduced the number of postoperative opioid prescriptions and the oral morphine equivalent per prescription.

Roger Colbran and colleagues have discovered new molecular details about the function of an enzyme with a key role in shaping learning and memory.

Post-transplantation diabetes mellitus (PTDM), a common complication of immunosuppressive drugs that are given to prevent transplant rejection, may be reversible and at least partially preventable, researchers at VUMC report.

A disease-associated mutation in a transporter protein causes cells to increase energy production, as if they are starving, ²¤ÂÜÊÓƵ researchers have discovered.

The John D. and Catherine T. MacArthur Foundation today unveiled a grant proposal from ²¤ÂÜÊÓƵ University Medical Center (VUMC) as one of the highest-scoring proposals, designated as the “Top 100,” in its 100&Change competition for a single $100 million grant to help solve one of the world’s most critical societal challenges.

Black men with high blood pressure could benefit from a research study beginning this month to check their vitals while they are getting a haircut at a barbershop.

A new algorithm for artificial intelligence-assisted calcium scoring can accurately determine cardiovascular risk across a range of CT scans and in a racially diverse population.

Erkan Karakas and colleagues used cryo-electron microscopy to determine structural details of a calcium channel protein that has numerous cell signaling roles.

A noninvasive MRI approach assesses breast tumor cell size and could be a useful way to evaluate early response to neoadjuvant therapy.

Timothy Cover and colleagues report new insights into the sources of energy used by a bacterial “machine” linked to the pathogenesis of stomach cancer.

A research team led by scientists at ²¤ÂÜÊÓƵ University Medical Center has developed an antibody mixture that in animals is highly effective in blocking infection by the Ebola virus.

Two ²¤ÂÜÊÓƵ University pharmacologists have won prestigious awards from the American Society for Pharmacology and Experimental Therapeutics (ASPET).

Beta-1 integrin, a critical component of epithelial extracellular matrix receptors, is essential for normal lung function in adulthood, researchers at VUMC have discovered.

²¤ÂÜÊÓƵ biochemists got unexpected results when they used their new approach to explore the role of DNA methylation in gene regulation.

MYC is a family of three related proteins that are overexpressed in cancer and which contribute to an estimated 100,000 cancer deaths annually in the United States. Understanding how MYC works could lead to the development of new drugs that can effectively block MYC and stop many cancers in their tracks.