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With the aid of a $75 million, five-year grant renewal, the Electronic Medical Records and Genomics Network (eMERGE) will venture beyond its current focus on monogenic disease to scoring research participants relative risk for complex heritable diseases such as cardiovascular disease, chronic kidney disease and type 2 diabetes.

The ²¤ÂÜÊÓƵ Institute for Clinical and Translational ²¤ÂÜÊÓƵ (VICTR), which provides comprehensive support for clinical and translational research at ²¤ÂÜÊÓƵ University Medical Center (VUMC), has been named Administrative Coordinating Center (ACC) of a national effort to streamline the research response to life-threatening lung and heart problems caused by COVID-19.

People with inoperable anal cancer treated with carboplatin-paclitaxel had fewer complications and lived longer than those who received another chemotherapy that has been more often administered.

Zinc supplementation did not reduce mortality, cardiovascular risk, levels of inflammation or microbial translocation among people with heavy alcohol use living with HIV/AIDS, according to a ²¤ÂÜÊÓƵ-led study.

²¤ÂÜÊÓƵ University Medical Center is evaluating razuprotafib, a drug used to treat glaucoma, in a new randomized, investigational trial for the prevention and treatment of acute respiratory distress syndrome (ARDS) in adult patients with moderate to severe COVID-19.

The insula, a small region of the brain involved in diverse brain functions had widespread dysconnectivity in schizophrenia, ²¤ÂÜÊÓƵ researchers found.

A single mutation in one gene can impair inhibitory signaling in the brain and cause multiple types of seizures and behavioral abnormalities.

The Outcomes Related to COVID-19 Treated with Hydroxychloroquine among In-patients with Symptomatic Disease (ORCHID) trial stopped enrolling new patients based on the fourth scheduled interim analysis showing no evidence of benefit or harm. 

After discovering a new mechanism for DNA damage repair last year, ²¤ÂÜÊÓƵ biochemists now provide direct evidence for how it works.

²¤ÂÜÊÓƵ cell biologists have developed an unbiased, quantitative framework for evaluating single-cell data.

On May 27, the All of Us ²¤ÂÜÊÓƵ Program launched the beta version of its cloud-based research platform, the ²¤ÂÜÊÓƵer Workbench.

²¤ÂÜÊÓƵ University Medical Center investigators have used high-throughput robotic technology to rapidly study and classify variations in a gene linked to heart rhythm disorders and cardiac conditions.

²¤ÂÜÊÓƵ University Medical Center scientists have identified a C. diff protein system that senses and captures heme (part of hemoglobin) to build a protective shield that fends off threats from our immune system and antibiotics.

After evaluating the ability of more than 1,500 monoclonal antibodies to bind and neutralize the COVID-19 virus, SARS-CoV-2, in the laboratory, AstraZeneca signed an exclusive license to six candidate antibodies in ²¤ÂÜÊÓƵ’s portfolio.

Staph bacteria may change the factor they use to activate blood clotting — to evade the immune response — a new study suggests.

Leslie Gewin and colleagues have upended conventional dogma about Wnt/beta-catenin signaling in the kidney, finding that it protects against chronic kidney disease rather than promoting it.

²¤ÂÜÊÓƵ researchers have discovered the involvement of a certain type of adenosine receptor in mediating signaling that supports tumor growth and metastasis.

The investigational antiviral drug remdesivir can shorten the time to recovery in adults hospitalized with COVID-19, according to preliminary results of a clinical trial published last month in The New England Journal of Medicine.

People with cancer sickened by COVID-19 have a crude death rate of 13%, according to the largest series of data released thus far from a multinational perspective. The data on more than 900 patients also revealed cancer-specific factors associated with increased mortality.

Renã Robinson, associate professor of chemistry, has been immersed in science-related activities and classes since she was a child. Today, she is leading a diverse lab of researchers, using chemistry to uncover clues surrounding Alzheimer’s disease. Read More