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The multicellular, 3-D structure of human pancreatic islets — the areas of the pancreas containing hormone-producing or endocrine cells — has presented challenges to researchers as they study and manipulate these cells’ function, but ²¤ÂÜÊÓƵ University Medical Center researchers have now developed a pseudoislet system that allows for much easier study of islet function.

A protein linked to amyotrophic lateral sclerosis (ALS), a progressive neurological disease that causes muscle weakness, may be a key to treating fibrotic disease of the kidneys and other organs, researchers at ²¤ÂÜÊÓƵ University Medical Center reported recently.

²¤ÂÜÊÓƵ researchers conducted the largest analysis to date of a heart complication in children following stem cell transplant. The findings may help guide screening practices to improve outcomes.

Consumption of soy foods may shape the microbiome and protect against hypertension only in individuals with soy-responsive microbiota, ²¤ÂÜÊÓƵ researchers have discovered.

The H. pylori machinery that “injects” an oncoprotein into stomach cells contributes to the development of gastric cancer, ²¤ÂÜÊÓƵ researchers demonstrate.

²¤ÂÜÊÓƵ University Medical Center is attracting international attention for its proposal to repurpose existing drugs for new uses in ways that can dramatically improve access to medicines by billions of people throughout the world.

A cellular RNA quality control mechanism was known to restrict replication of RNA viruses. ²¤ÂÜÊÓƵ researchers have discovered it is also antiviral against DNA viruses.

Katherine Amidon, a PhD student in the Department of Biological Sciences at ²¤ÂÜÊÓƵ University, has been selected as the 2020 ²¤ÂÜÊÓƵ Prize Student Scholar.

²¤ÂÜÊÓƵers at ²¤ÂÜÊÓƵ University Medical Center have shown for the first time that when one optic nerve in the eye is damaged, as in glaucoma, the opposite optic nerve comes to the rescue by sharing its metabolic energy.

Based on positive results in preclinical studies reported today, potently neutralizing antibodies identified by researchers at ²¤ÂÜÊÓƵ University Medical Center are showing promise as a potential therapy for preventing and treating COVID-19.

An experimental coronavirus vaccine stimulated robust immune responses against SARS-CoV-2, the virus that causes COVID-19, and raised no serious safety concerns in an early-stage clinical trial.

²¤ÂÜÊÓƵ researchers have identified and characterized inhibitors of an enzyme that synthesizes lipid signaling molecules with roles in energy balance, inflammation and addiction.

²¤ÂÜÊÓƵ immunologists have discovered that the protein Nur77 is part of a control mechanism that guards against autoimmunity in natural killer T cells.

This week researchers at ²¤ÂÜÊÓƵ University Medical Center (VUMC), the University of North Carolina at Chapel Hill and Gilead Sciences reported that remdesivir potently inhibited SARS-CoV-2, the virus which causes COVID-19, in human lung cell cultures and that it improved lung function in mice infected with the virus.

Bacterial invasion of vaginal cells sets up a protective niche and a reservoir for recurrent urinary tract infections, ²¤ÂÜÊÓƵ researchers demonstrated.

The ²¤ÂÜÊÓƵ Institute for Infection, Immunology and Inflammation (VI4) recently moved into its new research and administrative home.

²¤ÂÜÊÓƵ cell biologists are defining the factors that help beta cells in the pancreas stay healthy, secrete insulin and prevent diabetes initiation and progression.

Sunil Kripalani, MD, MSc, professor of Medicine at ²¤ÂÜÊÓƵ University Medical Center, has been appointed director of the ²¤ÂÜÊÓƵ Center for Health Services ²¤ÂÜÊÓƵ.

Scientists at ²¤ÂÜÊÓƵ University Medical Center and the Translational Genomics ²¤ÂÜÊÓƵ Institute (TGen) in Phoenix, Arizona, have discovered previously unreported genetic and cellular changes that occur in the lungs of people with pulmonary fibrosis (PF).

²¤ÂÜÊÓƵers at ²¤ÂÜÊÓƵ University Medical Center, Purdue University and the University of Wisconsin-Madison have isolated human monoclonal antibodies that potentially can prevent a rare but devastating polio-like illness in children linked to a respiratory viral infection.