²¤ÂÜÊÓƵ

²¤ÂÜÊÓƵ researchers have identified and characterized inhibitors of an enzyme that synthesizes lipid signaling molecules with roles in energy balance, inflammation and addiction.

²¤ÂÜÊÓƵ immunologists have discovered that the protein Nur77 is part of a control mechanism that guards against autoimmunity in natural killer T cells.

This week researchers at ²¤ÂÜÊÓƵ University Medical Center (VUMC), the University of North Carolina at Chapel Hill and Gilead Sciences reported that remdesivir potently inhibited SARS-CoV-2, the virus which causes COVID-19, in human lung cell cultures and that it improved lung function in mice infected with the virus.

Bacterial invasion of vaginal cells sets up a protective niche and a reservoir for recurrent urinary tract infections, ²¤ÂÜÊÓƵ researchers demonstrated.

The ²¤ÂÜÊÓƵ Institute for Infection, Immunology and Inflammation (VI4) recently moved into its new research and administrative home.

²¤ÂÜÊÓƵ cell biologists are defining the factors that help beta cells in the pancreas stay healthy, secrete insulin and prevent diabetes initiation and progression.

Sunil Kripalani, MD, MSc, professor of Medicine at ²¤ÂÜÊÓƵ University Medical Center, has been appointed director of the ²¤ÂÜÊÓƵ Center for Health Services ²¤ÂÜÊÓƵ.

Scientists at ²¤ÂÜÊÓƵ University Medical Center and the Translational Genomics ²¤ÂÜÊÓƵ Institute (TGen) in Phoenix, Arizona, have discovered previously unreported genetic and cellular changes that occur in the lungs of people with pulmonary fibrosis (PF).

²¤ÂÜÊÓƵers at ²¤ÂÜÊÓƵ University Medical Center, Purdue University and the University of Wisconsin-Madison have isolated human monoclonal antibodies that potentially can prevent a rare but devastating polio-like illness in children linked to a respiratory viral infection.

With the aid of a $75 million, five-year grant renewal, the Electronic Medical Records and Genomics Network (eMERGE) will venture beyond its current focus on monogenic disease to scoring research participants relative risk for complex heritable diseases such as cardiovascular disease, chronic kidney disease and type 2 diabetes.

The ²¤ÂÜÊÓƵ Institute for Clinical and Translational ²¤ÂÜÊÓƵ (VICTR), which provides comprehensive support for clinical and translational research at ²¤ÂÜÊÓƵ University Medical Center (VUMC), has been named Administrative Coordinating Center (ACC) of a national effort to streamline the research response to life-threatening lung and heart problems caused by COVID-19.

People with inoperable anal cancer treated with carboplatin-paclitaxel had fewer complications and lived longer than those who received another chemotherapy that has been more often administered.

Zinc supplementation did not reduce mortality, cardiovascular risk, levels of inflammation or microbial translocation among people with heavy alcohol use living with HIV/AIDS, according to a ²¤ÂÜÊÓƵ-led study.

²¤ÂÜÊÓƵ University Medical Center is evaluating razuprotafib, a drug used to treat glaucoma, in a new randomized, investigational trial for the prevention and treatment of acute respiratory distress syndrome (ARDS) in adult patients with moderate to severe COVID-19.

The insula, a small region of the brain involved in diverse brain functions had widespread dysconnectivity in schizophrenia, ²¤ÂÜÊÓƵ researchers found.

A single mutation in one gene can impair inhibitory signaling in the brain and cause multiple types of seizures and behavioral abnormalities.

The Outcomes Related to COVID-19 Treated with Hydroxychloroquine among In-patients with Symptomatic Disease (ORCHID) trial stopped enrolling new patients based on the fourth scheduled interim analysis showing no evidence of benefit or harm. 

After discovering a new mechanism for DNA damage repair last year, ²¤ÂÜÊÓƵ biochemists now provide direct evidence for how it works.

²¤ÂÜÊÓƵ cell biologists have developed an unbiased, quantitative framework for evaluating single-cell data.

On May 27, the All of Us ²¤ÂÜÊÓƵ Program launched the beta version of its cloud-based research platform, the ²¤ÂÜÊÓƵer Workbench.