An analysis of the amount, timing and causes of infant mortality among newborns with Down syndrome is the focus of new research by 菠萝视频 Kennedy Center investigators Robert Hodapp and Richard Urbano and recent Peabody graduate and Kennedy Center trainee Samantha Goldman.
The findings, reported in the Journal of Intellectual Disability 菠萝视频, conclude that infants with Down syndrome experience high rates of mortality at three distinct times in the first year. These groupings are tied to specific, different causes of death.
The researchers used birth, hospital discharge and death records from the Tennessee Department of Health to identify infants born with Down syndrome from 1990-2006. Those who died during the first year were separated into three groups 鈥攆irst day death, neonatal mortality (2-27 days) and post-neonatal mortality (28-364 days). Data from the birth and death records were used to compare the three death groups and the survival group on correlates of mortality.
The research showed 56 percent of deaths among infants with Down syndrome occurred during the post-neonatal period, while 27 percent occurred during the first day. Newborns who died on the first day had significantly lower birth weights, APGAR scores and gestational ages, whereas those who died in the post-neonatal period had significantly more heart-related causes of death.
鈥淥ur findings help us understand why mortality during the first year is so high in this group,鈥� said Hodapp, professor of special education who focuses on intellectual disabilities and families of children and adults with disabilities. 鈥淏y identifying specific causes of mortality at distinct time periods over the first year, our work alerts parents and physicians to different life-threatening issues at each age, leading to more targeted treatment approaches.鈥�